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Structural genomics / edited by Andrzej Joachimiak
(Advances in protein chemistry and structural biology ; v. 75)

1st ed.
出版者 Oxford ; Burlington, MA : Academic Press
出版年 2008
大きさ 1 online resource (ix, 153 pages) : illustrations (some color)
書誌ID MC00009246

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eBook オンライン資料

MC000048255
Elsevier ScienceDirect Books Complete 9780123744364

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一般注記 Includes bibliographical references and indexes.
Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. Key Features *Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy * Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission.
Print version record.
著者標目 Joachimiak, Andrzej
件 名 LCSH:Genomics
LCSH:Proteins -- Structure  この組合せで検索
FREE:Genomics
FREE:Proteins -- Structure  この組合せで検索
FREE:Eiwitten
FREE:Electronic books
FREE:Jaarboeken (vorm)
分 類 LCC:QH447
DC22:572.8633
資料種別 機械可読データファイル
巻冊次 ISBN:9780123744364
ISBN:0123744369
ISBN:0080922325
ISBN:9780080922324