Methods in protein design / edited by Amy E. Keating
(Methods in enzymology. ISSN:00766879 ; volume 523)
|出版者||San Diego, Calif : Academic|
|大きさ||1 online resource (xviii, 464 pages) : illustrations|
|一般注記|| Includes bibliographical references and indexes.
Computational design of novel protein binders and experimental affinity maturation -- Mining tertiary structural motifs for assessment of designability -- Computational methods for controlling binding specificity -- Flexible backbone sampling methods to model and design protein alternative conformations -- Osprey: protein design with ensembles, flexibility, and provable algorithms -- Scientific benchmarks for guiding macromolecular energy function improvement -- Molecular dynamics simulations for the ranking, evaluation, and refinement of computationally designed proteins -- Multistate protein design using CLEVER and CLASSY -- Using analyses of amino acid coevolution to understand protein structure and function -- Evolution-based design of proteins -- Protein engineering and stabilization from sequence statistics: variation and covariation analysis -- Enzyme engineering by targeted libraries -- Generation of high-performance binding proteins for pepetide motifs by affinity clamping -- Engineering fibronectin-based binding proteins by yeast surface display -- Engineering and analysis of peptide-recognition domain specificities by phage display and deep sequencing -- Efficient sampling of SCHEMA chimera families to identify useful sequence elements -- Protein switch engineering by domain insertion -- Design of chimeric proteins by combination of subdomain-sized fragments -- [alpha]-helix mimicry with [alpha/beta]-peptides
Print version record.
Elsevier ScienceDirect Book Series Package - Methods in Enzymology (2000-ongoing)
|著者標目||Keating, Amy E|
|件 名||LCSH:Protein engineering
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