Advances in genetics / edited by Theodore Friedmann, Jay Dunlap, Stephen Goodwin
|出版者||(Amsterdam : Academic Press)|
|大きさ||1 online resource|
|一般注記|| The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. * Includes methods for testing with ethical, legal, and social implications * Critically analyzes future.
Print version record.
Front Cover; Advances in Genetics; Copyright; Contents; Contributors; Chapter One: Biology and Mechanisms of Short RNAs in Caenorhabditis elegans; 1. Introduction; 2. miRNA Function; 2.1. Biological effects of miRNAs; 2.1.1. Developmental timing; 2.1.2. Embryonic development; 2.1.3. Postembryonic development; 2.1.4. Physiology; 2.1.5. Longevity and stress response; 2.2. Biogenesis and molecular mechanisms of miRNAs; 3. RNAi and Endogenous siRNAs; 3.1. Exogenous RNAi pathway; 3.1.1. RDE-4 and Dicer; 3.1.2. RDE-1 Argonaute protein; 3.1.3. siRNA amplification and additional Argonautes
3.1.4. Mutator proteins3.1.5. ABC transporters; 3.1.6. RDE-10/RDE-11 complex; 3.1.7. Transcriptional silencing induced by dsRNA; 3.1.8. Inheritance of dsRNA-induced gene silencing; 3.1.9. Chromatin modulators of the RNAi response; 3.2. Genomic and molecular features of endogenous RNAi; 3.2.1. Discovery of endo-siRNAs; 3.2.2. Distinction between WAGO- and CSR-1-associated 22G-endo-siRNAs; 3.2.3. 26G- and 22G-endo-siRNAs of the ERI pathway; 3.2.4. Competition between ADARs and endogenous RNAi; 3.3. Biological functions of RNAi; 3.3.1. Antiviral defense
3.3.2. Silencing of transposons and repetitive elements3.3.3. A summary of the global effects of 22G-RNAs on the expression of endogenous genes; 3.3.4. Endogenous RNAi and adaptation to environment; 3.3.5. Developmental roles of the CSR-1 22G-RNA pathway; 3.3.6. Cooperation between RNAi and Rb; 3.3.7. The role of ALG-3/4 endo-siRNAs in sperm development; 4. 21U-RNAs, C. elegans piRNAs; 4.1. Biogenesis of 21U-RNAs; 4.2. Biological functions of 21U-RNAs; 4.2.1. Function in fertility; 4.2.2. Connection between 21U-RNAs, 22G-RNA production, and stable silencing of foreign DNA
5. Systemic Features of RNAi5.1. dsRNA import channel SID-1 and the features of mobile RNA species; 5.2. Additional factors required for systemic and environmental RNAi; 5.2.1. SID-2; 5.2.2. SID-3; 5.2.3. SID-5; 6. Outlook; Acknowledgments; References; Chapter Two: Genetics of Immune Recognition and Response in Drosophila host defense; 1. Introduction; 1.1. Overview of Drosophila immune responses; 2. Toll Signaling in Drosophila; 2.1. Activation; 2.1.1. The Necrotic-Persephone axis; 2.1.2. PGRPs and GNBPs; 2.1.3. Mechanism of sensing bacterial and fungal cell wall components
2.1.4. Ligand activation: The role of Spz2.2. Intracellular signaling; 2.3. Host-pathogen interaction upstream of Toll; 3. The Immune Deficiency Pathway; 3.1. Recognition and intracellular signaling; 3.2. Gut immunity and IMD signaling; 3.3. Host-pathogen interaction; 4. Immunity as a Sensor of Metabolism; 5. Concluding Remarks-Future Directions; Acknowledgments; References; Chapter Three: Recent Advances in Septum Biogenesis in Neurospora crassa; 1. Introduction; 2. Septum Ontogeny; 2.1. Septation during hyphal development; 2.2. Septation establishment: Regulators and positional markers
|著者標目||Friedmann, Theodore 1935- editor
Dunlap, Jay C. editor
Goodwin, Stephen F. editor
FREE:SCIENCE -- Life Sciences -- Genetics & Genomics この組合せで検索